|
KMID : 0377619720230050461
|
|
Korean Jungang Medical Journal
1972 Volume.23 No. 5 p.461 ~ p.468
|
|
|
Electron Microscopic Study on the Endoplasmic Reticulum Changes after Long-Term Carbon Tetrachloride Administration
|
|
|
|
|
Abstract
|
|
|
The author was carried out light and electron microscopic investigation to delineate the intriguing endoplasmic reticulum changes of hepatocyte after long term exposure to carbon tetrachloride.
The female Sprague-Dawley albino rats were received subcutaneous injections-twice a week for thirteen weeks, of 0. 13 ml. 50 per cent solution of carbon tetrachloride in olive oil per 100 gm of body weight. In each instance, the rats were sacrificed three days after the last injection.
The control rats were not received any treatment. The results obtained are as follow:
1) The author´s findings on fine structure of endoplasmic reticulum in hepatocytes of normal rats are almost similar to that of other investigators.
2) The morphological effects of long-term administration of carbon tetrachloride upon the endoplasmic reticulum of hepatocyte are summarized as below.
I) Two types of morphologically altered hepatocytes are encountered. One of these, corresponding to slightly basophilic cell in the H-E preparation, is characterized by proliferation of rough-surfaced endoplasmic reticulum but slightly reduced as compare with normal hepatocyte. And the other is characterized by irregular arranged, dilated often cystic ally and reduced in reticulum with disappearance of RNP particles from its membrane which is correspond to eosinophilic and lipid-containing cell in the H-E presparation.
However various degree between these two extreme types are frequently-encountered.
ii) The elongated profiles fregment into short tubles or flattened vesicles resembling honey-comb appearance frequently in lipid-laden cells. These cells sometimes have enlarged Golgi.
3) These altered endoplasmic reticulum are belived to be degenerative changes after prolong exposure to carbon tetrachloride.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|